Ugi Four-Component Reaction Based on the<i>in situ</i>Capture of Amines and Subsequent Modification Tandem Cyclization Reaction: "One-Pot" Synthesis of Six- and Seven-Membered Heterocycles
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چکیده
منابع مشابه
Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2021
ISSN: ['0253-2786']
DOI: https://doi.org/10.6023/cjoc202012040